Tyr-2-methylalanine-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-2-methylalanine-Leu-Asp-Lys-Ile-Ala-Gln-N6-{N-(hydrogen icosanedioyl)-y-Glu-bis[iminobis(ethylenoxy)acetyl]}-Lys-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-L-serinamide

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Research areas: glucose metabolism:

Glucose-dependent stimulation of insulin secretion by beta cells

Suppression of glucagon secretion

Skinni: a dual GIP and GLP-1 receptor agonist peptide

Research areas: energy metabolism:

Central regulation of feeding behaviour

Gastric emptying rate

Insulin sensitivity of adipose and muscle tissue

Glucose uptake by muscle tissue

Lipolysis

Thermogenesis and energy expenditure

Other research areas:

Cardiovascular and metabolic markers

Skinni is a synthetic lipidated 39-amino-acid peptide, a dual agonist of the GIP and GLP-1 receptors. It is used in laboratory research on incretin signalling and the regulation of energy metabolism.

Unlike selective GLP-1 receptor agonists, the molecule activates both incretin receptors, GIP and GLP-1. This makes it useful in comparative studies of each receptor's contribution to cellular and tissue responses.

How it differs from mono-agonists:

Cellular insulin sensitivity

Cellular glucose uptake

Suppression of glucagon secretion

Glucose-dependent stimulation of insulin secretion by beta cells

Pancreatic beta-cell function

Research areas: glucose metabolism:

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INFO@JFC-LAB.COM

Dublin, Ireland

RU

ALL PRODUCTS PRESENTED ON THIS WEBSITE ARE INTENDED FOR RESEARCH PURPOSES ONLY. They are designed for in vitro testing and are strictly for use in laboratory experiments. All information provided on this website is for educational purposes only. Any administration of these products to humans or animals is strictly prohibited. It is essential that these products are handled only by licensed and qualified professionals. These products are not intended for use as drugs, food, or cosmetic products. They must not be mislabelled, misused, or misrepresented as such. Their intended purpose and use are strictly limited to scientific research.

Molecular Design of Recombinant Products

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[01]

Development of target protein or DNA sequences, insert, and vector design using in silico methods as part of R&D activities

[02]

Production of recombinant proteins

Bacterial expression

Eukaryotic expression

Development of purification methods for recombinant proteins as part of R&D activities

[03]

Molecular Biology Services

Gene synthesis

Cloning of sequences into vectors

[03]

Plasmid DNA Production

Bacterial expression

Development of purification methods for plasmid DNA as part of R&D activities

[05]

Peptide Synthesis

Gene Synthesis and Cloning of Genetic Constructs

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Our Capabilities

4 µg of lyophilized plasmid containing your gene insert

Sequence chromatogram covering your gene

Map of the final plasmid vector

Certificate of quality

Additional Options

Specialist assistance in construct design

Cloning of the insert into an expression vector

Free optimization of the gene sequence

Gene synthesis from 150 to 8000 base pairs

The cost of synthesis is calculated individually based on the GC content of the sequence, presence of repeats, complex structural elements (such as hairpins), and complex regulatory elements

Development of production strains

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Term from 4 weeks

Free Gene Optimization

Service of guaranteed protein production

We produce recombinant proteins in E.coli. We lead projects from design of amino acid sequence of protein and synthesis of genes to development of experimental and industrial regulations of recombinant protein substance production of pharmacopoeial quality

Analytics

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Verification of Sample Authenticity and Purity

N-terminal sequencing

Chromatography

Spectrometry

Quantitative analysis

HPLC, MS, NMR, GC

Accelerated aging

Stability testing

Preparation of Analytical Report

Purification

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Preparative purification of recombinant proteins and DNA

Preparative reversed-phase, normal-phase, hydrophobic, and ion-exchange chromatography

Purity level up to 99%

Technology

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Development of preparative purification technology for recombinant proteins and DNA

Drafting laboratory and industrial protocols

Technological process flowchart

Description of the technological process by stages. Material balance. Equipment requirements

Cost calculation

Scaling of the technological process

Consultation

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Providing consulting services as part of R&D

Study of patent, scientific, and technological literature

Literature and patent search

Preclinical and clinical studies, conditions, and results

Development of formulations for dietary supplements and cosmetics

CONTACT US

By clicking the "Submit" button, you agree to the Privacy Policy

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